YGMD deposits
(i)  33,024 CoopTFSs and their target GMs validated by TFB evidence (with # of genes in GM ≥ 15)
(ii) 1,096 CoopTFSs and their target GMs validated by TFB&TFR evidence (with # of genes in GM ≥ 5)

• The cooperativity between TFs in a CoopTFS is suggested by physical/genetic interaction evidence or/and predicted by existing algorithms.
• The target GM regulated by a CoopTFS is defined as the common target genes of all the TFs in that CoopTFS.
• The regulatory association between any TF in a CoopTFS and any gene in the target GM is supported by experimental evidence in the literature.

In YGMD, users can
(i) search the target GM regulated by a specific CoopTFS of interest
(ii) search all possible CoopTFSs whose target GMs contain a specific gene of interest

• YEASTRACT: a curated repository of approximately 163,000 regulatory associations between transcription factors (TF) and target genes in Saccharomyces cerevisiae.
• CoopTFD: a repository for 2,622 yeast cooperative transcription factors pairs predicted by 17 existing algorithms.
• YCRD: a repository of 434,197 regulatory associations between 2,535 cooperative TF pairs and 6,243 genes.

2017 Sept.: Allow users to browse all CoopTFSs which contain a TF of interset.
2017 Jun.: Release YGMD.
2017 Mar.: Download data sources from SGD, YEASTRACT, BioGRID, CoopTFD and YeastNet.
2016 Oct.: Start YGMD project.

Last Updated: 09/21/2017